Target
Pathways and gene expression affeted
Treatment effects
Disease impact
MetAP2 Inhibition
Cell cycle proteins CDK 2, 4, 6, Cyclin El, E2
Growth factor signaling P13K/Akt/mTOR
Angiogenesis VEGF-C VEGF-D bFGF
Hypoxia HIF1a CCL20
Tumor microenvironment Tregs MDSCsArginase
Cytostatic - growth arrest, normalization of key metabolic hormones, anti-angiogenic, anti-metastatic
Tumor growth inhibited (mono and in combination)Reduced metastasesMetabolic dysfunction correctedReversal of immune system suppressionReduced fibrosis