About Us

About SynDevRx

We are dedicated to making Metabo-Oncology a new cancer treatment modality.

The SynDevRx team includes an impressive roster of well-respected business leaders, clinical oncologists, leaders in academic research, professors from premier institutions and experienced drug development professionals.

Cancer is a complex, multifaceted disease that demands an inter-disciplinary approach to effectively address it. We’re founded on the principals of collaboration and integrated, multi-disciplinary teamwork. 

Cancer demands extraordinary resources to grow and to spread.

The Hallmarks of Cancer teaches us that starving cancer makes targeted treatments more effective. 

Our goal is to break cancer’s supply chain of blood, oxygen, and nutrients that enable cancer cells to proliferate and spread. 
We aim to accomplish this with our lead drug candidate evexomostat, which combines two clinically-validated approaches in cancer treatment (Anti-angiogenesis and metabolic controlinto one well-tolerated, convenient and effective drug

Combining these effects into one easy treatment is expected to work hand-in-hand with other cancer treatment modalities to attack cancer from multiple directions and improve patient outcomes.

Vision - Metabo-Oncology as a Backbone treatment

We see metabo-oncology – and evexomostat – as a backbone treatment for any cancer patient with systemic metabolic dysfunction (obesity, diabetes, insulin resistance) and/or highly vascularized tumors.

Used in combination with standard-of-care therapies, evexomostat complements the vision of integrated cancer treatment described long ago in “The Hallmarks of Cancer“.

Our Team

SynDevRx is led by biotech business veterans with deep experience in drug development, corporate governance, operations, finance and business development.

We take pride in running an innovative, results-oriented business in a cash-efficient manner. Since launching the company in 2007, the co-founders have surrounded themselves with an experienced and dedicated team of brilliant people who share their passion for bringing life-changing therapeutics to patients.

Bradley Carver

Co-Founder, Chairman of the Board, President and Chief Executive Officer

James M. Shanahan

Co-Founder, Chief Business Officer and Director

Senior Management

SynDevRx operates a lean organization.

Our team members have large-pharma, biotech, start-up and CRO experience giving SynDevRx well-balanced, professional guidance and program execution.

Peter Cornelius, Ph.D.

Senior Director, Translational Research

David Neafus, MBA, CPA

Consulting Chief Financial Officer

Benjamin Mayes, Ph.D.

Director, Process Development

David M. Browning, M.T., MBA

Consulting Clinical Operations Manager

Pierre J. Dufour, M.S.

Senior Director, Data Analytics

Lisa Koch-Hulle, RAC

co-Founder, Essential Regulatory

The SynDevRx Board of Directors includes our two co-founders along with outside board members who provide valuable insights into financing, clinical development and other aspects of our business.

All board members play an active role in shaping the direction and strategy of the company.

Michael Clifford

Director

Charles Flynn

Director

James M. Shanahan

Co-Founder, Chief Business Officer and Director

Bradley Carver

Co-Founder, Chairman of the Board, President and Chief Executive Officer

Jeffrey Wells

Director

The SynDevRx Scientific Advisory Board consists of world-renowned oncologists, clinical trial researchers and academic researchers whose collective expertise spans drug development, MetAP2 biology, oncology, metabo-oncology and angiogenesis.

The board members play a very hands-on role in our drug development program and clinical trials, offering crucial guidance on clinical trial strategy and design, indication selection, biomarker identification and end-point definition.

Breast Cancer Medical Advisors

Hope S. Rugo, M.D.

Professor, Department of Medical Oncology & Therapeutics, Research Division Chief, Breast Medical Oncology, Women's Cancers Program Director, City of Hope

Joyce O’Shaughnessy, M.D.

Director, Breast Cancer Research Program Texas Oncology, US Oncology

Neil M. Iyengar, MD

Co-Director, Breast Medical Oncology, Department of Hematology and Medical Oncology, Emory University School of Medicine

Lajos L. Pusztai, MD, DPhil

Chair of the Breast Cancer Research Committee of the South West Oncology Group (SWOG)

Prostate Cancer Medical Advisors

David M. Nanus, MD

Professor of Medicine, Weill Cornell Medical College

Ganesh Palapattu, MD, FACS

George F. and Sandy G. Valassis Professor and Chair of the Department of Urology, University of Michigan

Andrew L. Laccetti, MD

Associate Clinical Professor of Genitourinary Medical Oncology at NYU Langone Perlmutter Cancer Center, NYU Grossman School of Medicine

Philip Kantoff, MD

CEO, co-Founder, Convergent Therapeutics

Scientific Advisory Board (Chair, Bruce R. Zetter, PhD, Harvard Medical)

Andrew Dannenberg, M.D.

Medical Advisor (and SAB)

Emily J. Gallagher, MD, PhD

Medical Advisor (and SAB)

Roy S. Herbst, M.D., Ph.D.

Medical Advisor (and SAB)

Donald E. Ingber, M.D., Ph.D.

Medical, Scientific Advisor

Rakesh K. Jain, Ph.D.

Scientific Advisor

Daniel D. Von Hoff, M.D., FACP, FAACR, FASCO

Medical Advisor

For Investors

SDX demonstrates best-in-class fiscal responsibility and management. We have achieved clinical proof-of-concept in multiple cancer indications exclusively through private investors and grants. 

We operate transparently, have audited financials (under public accounting standards “PCAOB”) and we maintain a clean cap table. 

We would be happy to discuss our company with interested potential investors.

Discover more about how we’re shaping the future.

1 Broadway Fl. 14, Cambridge, MA 02142

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