We show that decellularized ECM from tumor-bearing and obese mammary glands drives
TNBC cell invasion. Proteomics of the ECM from the obese mammary gland led us to identify full-length collagen
VI as a novel driver of TNBC cell invasion whose abundance in tumor stroma increases with body mass index in
human TNBC patients. Last, we describe the mechanism by which collagen VI contributes to TNBC cell invasion via
NG2-EGFR cross-talk and MAPK signaling.
